CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase, accessory domain (PIK)
Functional Family Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P48736
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P48736
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P48736
PK3CG_HUMAN
Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB 6C1S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).
Come, J.H., Collier, P.N., Henderson, J.A., Pierce, A.C., Davies, R.J., Le Tiran, A., O'Dowd, H., Bandarage, U.K., Cao, J., Deininger, D., Grey, R., Krueger, E.B., Lowe, D.B., Liang, J., Liao, Y., Messersmith, D., Nanthakumar, S., Sizensky, E., Wang, J., Xu, J., Chin, E.Y., Damagnez, V., Doran, J.D., Dworakowski, W., Griffith, J.P., Jacobs, M.D., Khare-Pandit, S., Mahajan, S., Moody, C.S., Aronov, A.M.
J. Med. Chem.