CATH Classification

Domain Context

CATH Clusters

Superfamily 2.30.30.140
Functional Family Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q15047
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q15047
SETB1_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase SETDB1

PDB Structure

PDB 6BHI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Jurkowska, R.Z., Qin, S., Kungulovski, G., Tempel, W., Liu, Y., Bashtrykov, P., Stiefelmaier, J., Jurkowski, T.P., Kudithipudi, S., Weirich, S., Tamas, R., Wu, H., Dombrovski, L., Loppnau, P., Reinhardt, R., Min, J., Jeltsch, A.
Nat Commun