CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloenzyme, LuxS/M16 peptidase-like
Functional Family Insulin-degrading enzyme

Enzyme Information

3.4.24.56
Insulysin.
based on mapping to UniProt P14735
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.

UniProtKB Entries (1)

P01308
INS_HUMAN
Homo sapiens
Insulin

PDB Structure

PDB 6B3Q
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Zhang, Z., Liang, W.G., Bailey, L.J., Tan, Y.Z., Wei, H., Wang, A., Farcasanu, M., Woods, V.A., McCord, L.A., Lee, D., Shang, W., Deprez-Poulain, R., Deprez, B., Liu, D.R., Koide, A., Koide, S., Kossiakoff, A.A., Li, S., Carragher, B., Potter, C.S., Tang, W.J.
Elife