CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q13153
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13153
PAK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase PAK 1

PDB Structure

PDB 6B16
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.
Lee, W., Crawford, J.J., Aliagas, I., Murray, L.J., Tay, S., Wang, W., Heise, C.E., Hoeflich, K.P., La, H., Mathieu, S., Mintzer, R., Ramaswamy, S., Rouge, L., Rudolph, J.
Bioorg. Med. Chem. Lett.