CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1380.10
Functional Family

Enzyme Information

3.4.16.4
Serine-type D-Ala-D-Ala carboxypeptidase.
based on mapping to UniProt Q47746
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

Q47746
VANY_ENTFA
Enterococcus faecalis V583
D-alanyl-D-alanine carboxypeptidase

PDB Structure

PDB 5ZHW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the substrate recognition of peptidoglycan pentapeptides by Enterococcus faecalis VanYB.
Kim, H.S., Hahn, H., Kim, J., Jang, D.M., Lee, J.Y., Back, J.M., Im, H.N., Kim, H., Han, B.W., Suh, S.W.
Int. J. Biol. Macromol.