CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.630 | Aminopeptidase |
|
3.40.630.20 | Peptidase C15, pyroglutamyl peptidase I-like |
Domain Context
CATH Clusters
| Superfamily | Peptidase C15, pyroglutamyl peptidase I-like |
| Functional Family | Pyrrolidone-carboxylate peptidase |
Enzyme Information
| 3.4.19.3 |
Pyroglutamyl-peptidase I.
based on mapping to UniProt Q9RX25
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.
-!- Removes 5-oxoproline from various penultimate amino acid residues except L-proline. -!- Inhibited by thiol-blocking reagents. -!- Belongs to peptidase family C15. -!- Formerly EC 3.4.11.8.
|
UniProtKB Entries (1)
| Q9RX25 |
PCP_DEIRA
Deinococcus radiodurans R1
Pyrrolidone-carboxylate peptidase
|
PDB Structure
| PDB | 5Z48 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of pyrrolidone-carboxylate peptidase I from Deinococcus radiodurans reveal the mechanism of L-pyroglutamate recognition.
Acta Crystallogr D Struct Biol
|