CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.718 | Isopropylmalate Dehydrogenase |
|
3.40.718.10 | Isopropylmalate Dehydrogenase |
Domain Context
CATH Clusters
| Superfamily | Isopropylmalate Dehydrogenase |
| Functional Family | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial |
Enzyme Information
| 1.1.1.41 |
Isocitrate dehydrogenase (NAD(+)).
based on mapping to UniProt P50213
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.
-!- Unlike EC 1.1.1.42, oxalosuccinate cannot be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NADP(+) but much more slowly.
|
UniProtKB Entries (1)
| P51553 |
IDH3G_HUMAN
Homo sapiens
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
|
PDB Structure
| PDB | 5YVT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Insights into the inhibitory mechanisms of NADH on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
Sci Rep
|