CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Methionine--tRNA ligase, cytoplasmic

Enzyme Information

6.1.1.10
Methionine--tRNA ligase.
based on mapping to UniProt P56192
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.

UniProtKB Entries (1)

P07814
SYEP_HUMAN
Homo sapiens
Bifunctional glutamate/proline--tRNA ligase

PDB Structure

PDB 5Y6L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric glutathione transferase-homology domains in multi-tRNA synthetase complex
Cho, H.Y., Lee, H.J., Kang, B.S.
To be published