CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.26 | Dihydroorotate Dehydrogenase A; chain A, domain 2 |
|
2.30.26.10 | Dihydroorotate Dehydrogenase A, chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Dihydroorotate Dehydrogenase A, chain A, domain 2 |
| Functional Family | Dihydroorotate dehydrogenase (fumarate) |
Enzyme Information
| 1.3.98.1 |
Dihydroorotate oxidase (fumarate).
based on mapping to UniProt Q57U83
(S)-dihydroorotate + fumarate = orotate + succinate.
-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.
|
UniProtKB Entries (1)
| Q57U83 |
PYRD_TRYB2
Trypanosoma brucei brucei TREU927
Dihydroorotate dehydrogenase (fumarate)
|
PDB Structure
| PDB | 5XFW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase fromTrypanosoma brucei.
FEBS Open Bio
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