CATH Domain 5v49B03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.730	Isoleucyl-tRNA Synthetase; Domain 1
	1.10.730.10	Isoleucyl-tRNA Synthetase; Domain 1

Domain Context

CATH Clusters

Superfamily	Isoleucyl-tRNA Synthetase; Domain 1
Functional Family	Methionyl-tRNA synthetase, putative

Enzyme Information

UniProtKB Entries (1)

Q38C91_TRYB2

Trypanosoma brucei brucei TREU927

Methionyl-tRNA synthetase, putative

PDB Structure

PDB	5V49
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors. Huang, W., Zhang, Z., Ranade, R.M., Gillespie, J.R., Barros-Alvarez, X., Creason, S.A., Shibata, S., Verlinde, C.L.M.J., Hol, W.G.J., Buckner, F.S., Fan, E. Bioorg. Med. Chem. Lett.