CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.140 | Cytidine Deaminase; domain 2 | |
3.40.140.20 | AICAR transformylase, duplication domain |
Domain Context
CATH Clusters
Superfamily | 3.40.140.20 |
Functional Family | Bifunctional purine biosynthesis protein PURH |
Enzyme Information
2.1.2.3 |
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
based on mapping to UniProt P31939
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
|
3.5.4.10 |
IMP cyclohydrolase.
based on mapping to UniProt P31939
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
|
UniProtKB Entries (1)
P31939 |
PUR9_HUMAN
Homo sapiens
Bifunctional purine biosynthesis protein PURH
|
PDB Structure
PDB | 5UY8 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J. Med. Chem.
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