CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.140.20
Functional Family Bifunctional purine biosynthesis protein PURH

Enzyme Information

2.1.2.3
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
based on mapping to UniProt P31939
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
3.5.4.10
IMP cyclohydrolase.
based on mapping to UniProt P31939
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

P31939
PUR9_HUMAN
Homo sapiens
Bifunctional purine biosynthesis protein PURH

PDB Structure

PDB 5UY8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
Fales, K.R., Njoroge, F.G., Brooks, H.B., Thibodeaux, S., Torrado, A., Si, C., Toth, J.L., Mc Cowan, J.R., Roth, K.D., Thrasher, K.J., Frimpong, K., Lee, M.R., Dally, R.D., Shepherd, T.A., Durham, T.B., Margolis, B.J., Wu, Z., Wang, Y., Atwell, S., Wang, J., Hui, Y.H., Meier, T.I., Konicek, S.A., Geeganage, S.
J. Med. Chem.