CATH Classification

Domain Context

CATH Clusters

Superfamily ProC C-terminal domain-like
Functional Family Pyrroline-5-carboxylate reductase 1, mitochondrial

Enzyme Information

1.5.1.2
Pyrroline-5-carboxylate reductase.
based on mapping to UniProt P32322
L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
-!- Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.

UniProtKB Entries (1)

P32322
P5CR1_HUMAN
Homo sapiens
Pyrroline-5-carboxylate reductase 1, mitochondrial

PDB Structure

PDB 5UAT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1.
Christensen, E.M., Patel, S.M., Korasick, D.A., Campbell, A.C., Krause, K.L., Becker, D.F., Tanner, J.J.
J. Biol. Chem.