CATH Domain 5tpgA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.800	Phenylalanine Hydroxylase
	1.10.800.10	Aromatic amino acid hydroxylase

Domain Context

CATH Clusters

Superfamily	Aromatic amino acid hydroxylase
Functional Family	tryptophan 5-hydroxylase 1

Enzyme Information

1.14.16.4

Tryptophan 5-monooxygenase.

based on mapping to UniProt P17752

L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

-!- Activated by phosphorylation, catalyzed by a Ca(2+)-activated protein kinase. -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96. -!- The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.

UniProtKB Entries (1)

P17752

TPH1_HUMAN

Homo sapiens

Tryptophan 5-hydroxylase 1

PDB Structure

PDB	5TPG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Goldberg, D.R., De Lombaert, S., Aiello, R., Bourassa, P., Barucci, N., Zhang, Q., Paralkar, V., Stein, A.J., Holt, M., Valentine, J., Zavadoski, W. Bioorg. Med. Chem. Lett.