CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Mycocyclosin synthase

Enzyme Information

1.14.-.-
Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2).
based on mapping to UniProt P9WPP7
1.14.19.70
Mycocyclosin synthase.
based on mapping to UniProt P9WPP7
Cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O.
-!- A cytochrome P450 (heme-thiolate) protein from the bacterium Mycobacterium tuberculosis catalyzing an oxidative reaction that does not incorporate oxygen into the product. -!- Formerly EC 1.14.21.9.

UniProtKB Entries (1)

P9WPP7
CP121_MYCTU
Mycobacterium tuberculosis H37Rv
Mycocyclosin synthase

PDB Structure

PDB 5OP9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation.
Taban, I.M., Elshihawy, H.E.A.E., Torun, B., Zucchini, B., Williamson, C.J., Altuwairigi, D., Ngu, A.S.T., McLean, K.J., Levy, C.W., Sood, S., Marino, L.B., Munro, A.W., de Carvalho, L.P.S., Simons, C.
J. Med. Chem.