CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease A-like domain
Functional Family Ribonuclease pancreatic

Enzyme Information
Pancreatic ribonuclease.
based on mapping to UniProt P61823
(1) An (RNA) containing cytidine + H(2)O = an (RNA)-3'-cytidine- 3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA). (2) An (RNA) containing uridine + H(2)O = an (RNA)-3'-uridine- 3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).
-!- Specifically cleaves at the 3'-side of pyrimidine (uracil or cytosine) phosphate bonds in RNA. -!- The reaction takes place in two steps, with the 2',3'-cyclic phosphodiester intermediates released from the enzyme at the completion of the first step. -!- Hydrolysis of these cyclic compounds occurs at a much slower rate through a reversal of the first step, in which the -OH group of water substitutes for the 2'-OH group of the ribose used in the first step, and does not take place until essentially all the susceptible 3',5'-phosphodiester bonds have been cyclised. -!- The enzyme can act as an endo- or exo ribonuclease. -!- Formerly EC, EC and EC

UniProtKB Entries (1)

Bos taurus
Ribonuclease pancreatic

PDB Structure

External Links
Primary Citation
Ru-Based CO releasing molecules with azole ligands: interaction with proteins and the CO release mechanism disclosed by X-ray crystallography.
Pontillo, N., Ferraro, G., Messori, L., Tamasi, G., Merlino, A.
Dalton Trans