CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family SRSF protein kinase 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P78362
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P78362
SRPK2_HUMAN
Homo sapiens
SRSF protein kinase 2

PDB Structure

PDB 5MYV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
Batson, J., Toop, H.D., Redondo, C., Babaei-Jadidi, R., Chaikuad, A., Wearmouth, S.F., Gibbons, B., Allen, C., Tallant, C., Zhang, J., Du, C., Hancox, J.C., Hawtrey, T., Da Rocha, J., Griffith, R., Knapp, S., Bates, D.O., Morris, J.C.
ACS Chem. Biol.