CATH Classification

Domain Context

CATH Clusters

Superfamily tricorn interacting facor f3 domain
Functional Family Leucyl-cystinyl aminopeptidase

Enzyme Information

3.4.11.3
Cystinyl aminopeptidase.
based on mapping to UniProt Q9UIQ6
Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half- cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.
-!- Belongs to peptidase family M1.

UniProtKB Entries (1)

Q9UIQ6
LCAP_HUMAN
Homo sapiens
Leucyl-cystinyl aminopeptidase

PDB Structure

PDB 5MJ6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.
Mpakali, A., Saridakis, E., Harlos, K., Zhao, Y., Kokkala, P., Georgiadis, D., Giastas, P., Papakyriakou, A., Stratikos, E.
J. Med. Chem.