CATH Domain 5lv5A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	Protein arginine N-methyltransferase 6

Enzyme Information

2.1.1.319

Type I protein arginine methyltransferase.

based on mapping to UniProt Q6NZB1

2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L- homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.

-!- This eukaryotic enzyme catalyzes the sequential dimethylation of one of the terminal guanidino nitrogen atoms in arginine residues, resulting in formation of asymmetric dimethylarginine residues. -!- Some forms (e.g. PRMT1) have a very wide substrate specificity, while others (e.g. PRMT4 and PRMT6) are rather specific. -!- The enzyme has a preference for methylating arginine residues that are flanked by one or more glycine residues. -!- PRMT1 is responsible for the bulk (about 85%) of total protein arginine methylation activity in mammalian cells. -!- Cf. EC 2.1.1.320, EC 2.1.1.321 and EC 2.1.1.322. -!- Formerly EC 2.1.1.23, EC 2.1.1.124, EC 2.1.1.125 and EC 2.1.1.126.

UniProtKB Entries (1)

Q6NZB1

ANM6_MOUSE

Mus musculus

Protein arginine N-methyltransferase 6

PDB Structure

PDB	5LV5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Halby, L., Marechal, N., Pechalrieu, D., Cura, V., Franchini, D.M., Faux, C., Alby, F., Troffer-Charlier, N., Kudithipudi, S., Jeltsch, A., Aouadi, W., Decroly, E., Guillemot, J.C., Page, P., Ferroud, C., Bonnefond, L., Guianvarc'h, D., Cavarelli, J., Arimondo, P.B. Philos. Trans. R. Soc. Lond., B, Biol. Sci.