CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial

Enzyme Information

1.3.1.104
Enoyl-[acyl-carrier-protein] reductase.
based on mapping to UniProt Q8WZM3
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
-!- The enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl- carrier protein, in an NADPH-dependent manner. -!- This entry stands for enzymes whose stereo-specificity with respect to NADP(+) is not known (cf. EC 1.3.1.39, EC 1.3.1.10 and EC 1.3.1.9).

UniProtKB Entries (1)

Q8WZM3
ETR1_CANTR
Candida tropicalis
Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial

PDB Structure

PDB 5LBX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A conserved threonine prevents self-intoxication of enoyl-thioester reductases.
Rosenthal, R.G., Vogeli, B., Wagner, T., Shima, S., Erb, T.J.
Nat. Chem. Biol.