CATH Classification

Domain Context

CATH Clusters

Superfamily Retinoid X Receptor
Functional Family Retinoic acid receptor RXR-alpha

Enzyme Information

UniProtKB Entries (1)

P55055
NR1H2_HUMAN
Homo sapiens
Oxysterols receptor LXR-beta

PDB Structure

PDB 5KYJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Tice, C.M., Noto, P.B., Fan, K.Y., Zhao, W., Lotesta, S.D., Dong, C., Marcus, A.P., Zheng, Y.J., Chen, G., Wu, Z., Van Orden, R., Zhou, J., Bukhtiyarov, Y., Zhao, Y., Lipinski, K., Howard, L., Guo, J., Kandpal, G., Meng, S., Hardy, A., Krosky, P., Gregg, R.E., Leftheris, K., McKeever, B.M., Singh, S.B., Lala, D., McGeehan, G.M., Zhuang, L., Claremon, D.A.
Bioorg.Med.Chem.Lett.