CATH Domain 5jptB04

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.2130	DEAH helicase family, winged-helix domain

Domain Context

CATH Clusters

Superfamily	DEAH helicase family, winged-helix domain
Functional Family	Pre-mRNA-splicing factor ATP-dependent RNA helicase

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt P53131

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P53131

PRP43_YEAST

Saccharomyces cerevisiae S288C

Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

PDB Structure

PDB	5JPT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Functional link between DEAH/RHA helicase Prp43 activation and ATP base binding. Robert-Paganin, J., Halladjian, M., Blaud, M., Lebaron, S., Delbos, L., Chardon, F., Capeyrou, R., Humbert, O., Henry, Y., Henras, A.K., Rety, S., Leulliot, N. Nucleic Acids Res.