CATH Classification

Domain Context

CATH Clusters

Superfamily DEAH helicase family, winged-helix domain
Functional Family Pre-mRNA-splicing factor ATP-dependent RNA helicase

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P53131
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P53131
PRP43_YEAST
Saccharomyces cerevisiae S288C
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

PDB Structure

PDB 5JPT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Functional link between DEAH/RHA helicase Prp43 activation and ATP base binding.
Robert-Paganin, J., Halladjian, M., Blaud, M., Lebaron, S., Delbos, L., Chardon, F., Capeyrou, R., Humbert, O., Henry, Y., Henras, A.K., Rety, S., Leulliot, N.
Nucleic Acids Res.