CATH Classification

Domain Context

CATH Clusters

Superfamily Terpene synthase, N-terminal domain
Functional Family Isoprene synthase, chloroplastic

Enzyme Information

4.2.3.61
5-epiaristolochene synthase.
based on mapping to UniProt Q40577
(2E,6E)-farnesyl diphosphate = (+)-5-epiaristolochene + diphosphate.
-!- Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.

UniProtKB Entries (1)

Q40577
5EAS_TOBAC
Nicotiana tabacum
5-epi-aristolochene synthase

PDB Structure

PDB 5IL3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
To Be Published