CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1100
Functional Family Cysteine synthase

Enzyme Information

2.5.1.113
[CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
based on mapping to UniProt P9WP53
O-phospho-L-serine + [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH = [CysO sulfur-carrier protein]-Gly-NH-CH(2)-C(O)-S-L-cysteine + phosphate.
-!- The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor. -!- The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O(3)-acetyl-L-serine (cf. EC 2.5.1.65). -!- Formerly EC 2.5.1.n5.

UniProtKB Entries (1)

P9WP53
CYSM_MYCTU
Mycobacterium tuberculosis H37Rv
O-phosphoserine sulfhydrylase

PDB Structure

PDB 5I6D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
Brunner, K., Maric, S., Reshma, R.S., Almqvist, H., Seashore-Ludlow, B., Gustavsson, A.L., Poyraz, O., Yogeeswari, P., Lundback, T., Vallin, M., Sriram, D., Schnell, R., Schneider, G.
J.Med.Chem.