CATH Classification

Domain Context

CATH Clusters

Superfamily Hepatocyte Growth Factor
Functional Family Coagulation factor XI

Enzyme Information

3.4.21.27
Coagulation factor XIa.
based on mapping to UniProt P03951
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P01042
KNG1_HUMAN
Homo sapiens
Kininogen-1

PDB Structure

PDB 5I25
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Wong, S.S., stergaard, S., Hall, G., Li, C., Williams, P.M., Stennicke, H., Emsley, J.
Blood