CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family 3-phosphoinositide-dependent protein kinase 1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O15530
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O15530
PDPK1_HUMAN
Homo sapiens
3-phosphoinositide-dependent protein kinase 1

PDB Structure

PDB 5HKM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of novel 7-azaindoles as PDK1 inhibitors.
Wucherer-Plietker, M., Merkul, E., Muller, T.J., Esdar, C., Knochel, T., Heinrich, T., Buchstaller, H.P., Greiner, H., Dorsch, D., Finsinger, D., Calderini, M., Bruge, D., Gradler, U.
Bioorg.Med.Chem.Lett.