CATH Classification

Domain Context

CATH Clusters

Superfamily Met-10+ protein-like domains
Functional Family tRNA (guanine(37)-N1)-methyltransferase

Enzyme Information

2.1.1.228
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt Q9V2G1
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.
2.1.1.-
Methyltransferases.
based on mapping to UniProt Q9V2G1

UniProtKB Entries (1)

Q9V2G1
TAW22_PYRAB
Pyrococcus abyssi GE5
TRNA (guanine(37)-N1)/4-demethylwyosine(37)-methyltransferase Taw22

PDB Structure

PDB 5HJM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the bifunctional tRNA methyltransferase Trm5a
Wang, C., Jia, Q., Chen, R., Wei, Y., Li, J., Ma, J., Xie, W.
Sci Rep