CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.300 | GMP Synthetase; Chain A, domain 3 | |
3.30.300.110 | Met-10+ protein-like domains |
Domain Context
CATH Clusters
Superfamily | Met-10+ protein-like domains |
Functional Family | tRNA (guanine(37)-N1)-methyltransferase |
Enzyme Information
2.1.1.228 |
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt Q9V2G1
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.
|
2.1.1.- |
Methyltransferases.
based on mapping to UniProt Q9V2G1
|
UniProtKB Entries (1)
Q9V2G1 |
TAW22_PYRAB
Pyrococcus abyssi GE5
TRNA (guanine(37)-N1)/4-demethylwyosine(37)-methyltransferase Taw22
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PDB Structure
PDB | 5HJM |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structures of the bifunctional tRNA methyltransferase Trm5a
Sci Rep
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