CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.40 | Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A |
|
2.70.40.10 | Deoxyuridine triphosphatase (dUTPase) |
Domain Context
CATH Clusters
| Superfamily | 2.70.40.10 |
| Functional Family | Deoxyuridine triphosphatase |
Enzyme Information
| 3.6.1.23 |
dUTP diphosphatase.
based on mapping to UniProt P33316
dUTP + H(2)O = dUMP + diphosphate.
|
UniProtKB Entries (1)
| P33316 |
DUT_HUMAN
Homo sapiens
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
|
PDB Structure
| PDB | 5H4J |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy.
Mol. Cancer Ther.
|