CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidylprolyl isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q00688
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P42345
MTOR_HUMAN
Homo sapiens
Serine/threonine-protein kinase mTOR

PDB Structure

PDB 5GPG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells
Lee, S.Y., Lee, H., Lee, H.K., Lee, S.W., Ha, S.C., Kwon, T., Seo, J.K., Lee, C., Rhee, H.W.
Acs Cent.Sci.