CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.40.20
Functional Family DNA-directed RNA polymerase II subunit RPB1

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P04051
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q04307
RPC10_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase III subunit RPC10

PDB Structure

PDB 5FJ8
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Molecular Structures of Unbound and Transcribing RNA Polymerase III.
Hoffmann, N.A., Jakobi, A.J., Moreno-Morcillo, M., Glatt, S., Kosinski, J., Hagen, W.J.H., Sachse, C., Muller, C.W.
Nature