CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.60 | 4-Layer Sandwich | |
3.60.20 | Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 | |
3.60.20.10 | Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 |
Domain Context
CATH Clusters
Superfamily | Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 |
Functional Family | Proteasome subunit beta type-5 |
Enzyme Information
3.4.25.1 |
Proteasome endopeptidase complex.
based on mapping to UniProt P30656
Cleavage of peptide bonds with very broad specificity.
-!- A 20-S protein composed of 28 subunits arranged in four rings of seven. -!- The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity. -!- In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities. -!- The molecule is barrel-shaped, and the active sites are on the inner surfaces. -!- Terminal apertures restrict access of substrates to the active sites. -!- Inhibited by mercurial reagents and some inhibitors of serine endopeptidases. -!- Belongs to peptidase family T1. -!- Formerly EC 3.4.22.21, EC 3.4.24.5 and EC 3.4.99.46.
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UniProtKB Entries (1)
P23724 |
PSB6_YEAST
Saccharomyces cerevisiae S288C
Proteasome subunit beta type-6
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PDB Structure
PDB | 5FGF |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
Nat Commun
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