CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Possible thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P07607
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P07607
TYSY_MOUSE
Mus musculus
Thymidylate synthase

PDB Structure

PDB 5FCT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme
Dowiercial, A., Jarmula, A., Wilk, P., Rypniewski, W., Kowalska, M., Fraczyk, T., Ciesla, J., Rode, W.
Struct Chem