CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt Q9JZ38
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

Q9JZ38
CLPP_NEIMB
Neisseria meningitidis MC58
ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB 5DKP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.
Goodreid, J.D., Janetzko, J., Santa Maria, J.P., Wong, K.S., Leung, E., Eger, B.T., Bryson, S., Pai, E.F., Gray-Owen, S.D., Walker, S., Houry, W.A., Batey, R.A.
J.Med.Chem.