CATH Classification

Domain Context

CATH Clusters

Superfamily DNA-directed RNA polymerase, subunit 2, domain 6
Functional Family DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P08518
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P27999
RPB9_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase II subunit RPB9

PDB Structure

PDB 5C4X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
Barnes, C.O., Calero, M., Malik, I., Graham, B.W., Spahr, H., Lin, G., Cohen, A.E., Brown, I.S., Zhang, Q., Pullara, F., Trakselis, M.A., Kaplan, C.D., Calero, G.
Mol.Cell