CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Tissue-type plasminogen activator

Enzyme Information

3.4.21.68
T-plasminogen activator.
based on mapping to UniProt P00750
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- From a wide variety of mammalian tissues, especially endothelial cells. -!- Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. -!- Activity is considerably enhanced by fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00750
TPA_HUMAN
Homo sapiens
Tissue-type plasminogen activator

PDB Structure

PDB 5BRR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1
Gong, L., Liu, M., Zeng, T., Shi, X., Yuan, C., Andreasen, P.A., Huang, M.
J.Biol.Chem.