CATH Classification

Domain Context

CATH Clusters

Superfamily B-lactam Antibiotic, Isopenicillin N Synthase; Chain
Functional Family aspartyl/asparaginyl beta-hydroxylase isoform X2

Enzyme Information

1.14.11.16
Peptide-aspartate beta-dioxygenase.
based on mapping to UniProt Q12797
Peptide L-aspartate + 2-oxoglutarate + O(2) = peptide 3-hydroxy-L- aspartate + succinate + CO(2).
-!- Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.

UniProtKB Entries (1)

Q12797
ASPH_HUMAN
Homo sapiens
Aspartyl/asparaginyl beta-hydroxylase

PDB Structure

PDB 5APA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.
Pfeffer, I., Brewitz, L., Krojer, T., Jensen, S.A., Kochan, G.T., Kershaw, N.J., Hewitson, K.S., McNeill, L.A., Kramer, H., Munzel, M., Hopkinson, R.J., Oppermann, U., Handford, P.A., McDonough, M.A., Schofield, C.J.
Nat Commun