CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Cholesterol side-chain cleavage enzyme, mitochondrial

Enzyme Information

1.14.15.5
Corticosterone 18-monooxygenase.
based on mapping to UniProt P19099
Corticosterone + 2 reduced adrenodoxin + O(2) + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H(2)O.
1.14.15.4
Steroid 11-beta-monooxygenase.
based on mapping to UniProt P19099
A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O.
-!- Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone. -!- Formerly EC 1.14.1.6 and EC 1.99.1.7.

UniProtKB Entries (1)

P19099
C11B2_HUMAN
Homo sapiens
Cytochrome P450 11B2, mitochondrial

PDB Structure

PDB 4ZGX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.
Martin, R.E., Aebi, J.D., Hornsperger, B., Krebs, H.J., Kuhn, B., Kuglstatter, A., Alker, A.M., Marki, H.P., Muller, S., Burger, D., Ottaviani, G., Riboulet, W., Verry, P., Tan, X., Amrein, K., Mayweg, A.V.
J.Med.Chem.