CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt O00444
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

O00444
PLK4_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK4

PDB Structure

PDB 4YUR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Wong, Y.L., Anzola, J.V., Davis, R.L., Yoon, M., Motamedi, A., Kroll, A., Seo, C.P., Hsia, J.E., Kim, S.K., Mitchell, J.W., Mitchell, B.J., Desai, A., Gahman, T.C., Shiau, A.K., Oegema, K.
Science