CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamine synthetase/guanido kinase, catalytic domain
Functional Family Glutamine synthetase

Enzyme Information

6.3.1.2
Glutamine synthetase.
based on mapping to UniProt P9WN38
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.

UniProtKB Entries (1)

P9WN38
GLN1B_MYCTO
Mycobacterium tuberculosis CDC1551
Glutamine synthetase

PDB Structure

PDB 4XYC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies.
Couturier, C., Silve, S., Morales, R., Pessegue, B., Llopart, S., Nair, A., Bauer, A., Scheiper, B., Poverlein, C., Ganzhorn, A., Lagrange, S., Bacque, E.
Bioorg.Med.Chem.Lett.