CATH Domain 4wwnA03

Note: The assignment for domain 4wwnA03 was not available when the latest CATH+ database (v4_3_0) was released. The information below comes from putative assignments made in our daily snapshot: CATH-B. These assignments have gone through fewer checks than information from a CATH+ release.

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.70	Phosphatidylinositol 3-kinase, accessory domain (PIK)

Domain Context

CATH Clusters

Superfamily
Functional Family	-

PDB Structure

PDB	4WWN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease. Cushing, T.D., Hao, X., Shin, Y., Andrews, K., Brown, M., Cardozo, M., Chen, Y., Duquette, J., Fisher, B., Gonzalez-Lopez de Turiso, F., He, X., Henne, K.R., Hu, Y.L., Hungate, R., Johnson, M.G., Kelly, R.C., Lucas, B., McCarter, J.D., McGee, L.R., Medina, J.C., San Miguel, T., Mohn, D., Pattaropong, V., Pettus, L.H., Reichelt, A., Rzasa, R.M., Seganish, J., Tasker, A.S., Wahl, R.C., Wannberg, S., Whittington, D.A., Whoriskey, J., Yu, G., Zalameda, L., Zhang, D., Metz, D.P. J.Med.Chem.