CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Interleukin-1 receptor-associated kinase 4

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9NWZ3
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9NWZ3
IRAK4_HUMAN
Homo sapiens
Interleukin-1 receptor-associated kinase 4

PDB Structure

PDB 4U97
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Ferrao, R., Zhou, H., Shan, Y., Liu, Q., Li, Q., Shaw, D.E., Li, X., Wu, H.
Mol.Cell