CATH Classification

Domain Context

CATH Clusters

Superfamily Creatinase/methionine aminopeptidase superfamily
Functional Family xaa-Pro aminopeptidase 2

Enzyme Information

3.4.11.9
Xaa-Pro aminopeptidase.
based on mapping to UniProt O44750
Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
-!- Generally membrane bound enzyme present in both mammalian and bacterial cells. -!- Belongs to peptidase family M24B.

UniProtKB Entries (1)

O44750
XPP_CAEEL
Caenorhabditis elegans
Xaa-Pro aminopeptidase app-1

PDB Structure

PDB 4S2T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site.
Iyer, S., La-Borde, P.J., Payne, K.A., Parsons, M.R., Turner, A.J., Isaac, R.E., Acharya, K.R.
FEBS Open Bio