CATH Classification

Domain Context

CATH Clusters

Superfamily Calcium-transporting ATPase, cytoplasmic transduction domain A
Functional Family Sodium/potassium-transporting ATPase subunit alpha

Enzyme Information

7.2.2.13
Na(+)/K(+)-exchanging ATPase.
based on mapping to UniProt P05024
ATP + H(2)O + Na(+)(Side 1) + K(+)(Side 2) = ADP + phosphate + Na(+)(Side 2) + K(+)(Side 1).
-!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- An enzyme from the plasma membrane of animal cells that catalyzes the efflux of three Na(+) and influx of two K(+) per ATP hydrolyzed. -!- It is involved in generating the plasma membrane electrical potential. -!- Formerly EC 3.6.1.37 and EC 3.6.3.9.

UniProtKB Entries (1)

P05027
AT1B1_PIG
Sus scrofa
Sodium/potassium-transporting ATPase subunit beta-1

PDB Structure

PDB 4RET
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex.
Laursen, M., Gregersen, J.L., Yatime, L., Nissen, P., Fedosova, N.U.
Proc.Natl.Acad.Sci.USA