CATH Classification

Domain Context

CATH Clusters

Superfamily Glycogen Phosphorylase B;
Functional Family Glycogen [starch] synthase

Enzyme Information

2.4.1.11
Glycogen(starch) synthase.
based on mapping to UniProt Q9U2D9
UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha- D-glucosyl)(n+1).
-!- The description (official name) varies according to the source of the enzyme and the nature of its synthetic product. -!- Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. -!- The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186. -!- A similar enzyme utilizes ADP-glucose (cf. EC 2.4.1.21).

UniProtKB Entries (1)

H2KYQ5
GYG1_CAEEL
Caenorhabditis elegans
Glycogenin-1

PDB Structure

PDB 4QLB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the recruitment of glycogen synthase by glycogenin.
Zeqiraj, E., Tang, X., Hunter, R.W., Garcia-Rocha, M., Judd, A., Deak, M., von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J.J., Tyers, M., Sakamoto, K., Sicheri, F.
Proc.Natl.Acad.Sci.USA