CATH Classification

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family Acireductone dioxygenase

Enzyme Information

1.13.11.53
Acireductone dioxygenase (Ni(2+)-requiring).
based on mapping to UniProt Q81MI9
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + formate + CO.
-!- If Fe(2+) is bound instead of Ni(2+), the reaction catalyzed by EC 1.13.11.54 occurs instead. -!- The enzyme from Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC 8724 is involved in the methionine salvage pathway.
1.13.11.54
Acireductone dioxygenase (Fe(2+)-requiring).
based on mapping to UniProt Q81MI9
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2- oxobutanoate + formate.
-!- If Ni(2+) is bound instead of Fe(2+), the reaction catalyzed by EC 1.13.11.53 occurs instead. -!- The enzyme from Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC 8724 is involved in the methionine salvage pathway.

UniProtKB Entries (1)

Q81MI9
MTND_BACAN
Bacillus anthracis
Acireductone dioxygenase

PDB Structure

PDB 4QGM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Acireductone dioxygenase from Bacillus anthracis with cadmium ion in active center
Milaczewska, A.M., Chruszcz, M., Shabalin, I.G., Cooper, D.R., Borowski, T., Minor, W.
To be Published