CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.128.20
Functional Family Prostaglandin-H2 D-isomerase

Enzyme Information

5.3.99.2
Prostaglandin-D synthase.
based on mapping to UniProt P41222
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.

UniProtKB Entries (1)

P41222
PTGDS_HUMAN
Homo sapiens
Prostaglandin-H2 D-isomerase

PDB Structure

PDB 4OS8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase.
Perduca, M., Bovi, M., Bertinelli, M., Bertini, E., Destefanis, L., Carrizo, M.E., Capaldi, S., Monaco, H.L.
Acta Crystallogr.,Sect.D