CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Functional Family RNA demethylase ALKBH5

Enzyme Information

1.14.11.53
mRNA N(6)-methyladenine demethylase.
based on mapping to UniProt Q6P6C2
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).
-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.

UniProtKB Entries (1)

Q6P6C2
ALKB5_HUMAN
Homo sapiens
RNA demethylase ALKBH5

PDB Structure

PDB 4NRO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
Feng, C., Liu, Y., Wang, G., Deng, Z., Zhang, Q., Wu, W., Tong, Y., Cheng, C., Chen, Z.
J.Biol.Chem.