CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tau tubulin kinase 2b

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q5TCY1
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q5TCY1
TTBK1_HUMAN
Homo sapiens
Tau-tubulin kinase 1

PDB Structure

PDB 4NFN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.
Kiefer, S.E., Chang, C.J., Kimura, S.R., Gao, M., Xie, D., Zhang, Y., Zhang, G., Gill, M.B., Mastalerz, H., Thompson, L.A., Cacace, A.M., Sheriff, S.
Acta Crystallogr F Struct Biol Commun