CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin S

Enzyme Information

3.4.22.27
Cathepsin S.
based on mapping to UniProt O70370
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
-!- A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

O70370
CATS_MOUSE
Mus musculus
Cathepsin S

PDB Structure

PDB 4MZO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.
Hilpert, H., Mauser, H., Humm, R., Anselm, L., Kuehne, H., Hartmann, G., Gruener, S., Banner, D.W., Benz, J., Gsell, B., Kuglstatter, A., Stihle, M., Thoma, R., Sanchez, R.A., Iding, H., Wirz, B., Haap, W.
J.Med.Chem.