CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.70 | Cathepsin B; Chain A | |
3.90.70.10 | Cysteine proteinases |
Domain Context
CATH Clusters
Superfamily | Cysteine proteinases |
Functional Family | Cathepsin S |
Enzyme Information
3.4.22.27 |
Cathepsin S.
based on mapping to UniProt O70370
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
-!- A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH. -!- Belongs to peptidase family C1.
|
UniProtKB Entries (1)
O70370 |
CATS_MOUSE
Mus musculus
Cathepsin S
|
PDB Structure
PDB | 4MZO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.
J.Med.Chem.
|