CATH Classification

Domain Context

CATH Clusters

Superfamily Spermadhesin, CUB domain
Functional Family complement C1s subcomponent

Enzyme Information

3.4.21.42
Complement subcomponent C1s.
based on mapping to UniProt P09871
Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.
-!- Activated from proenzyme C1s in plasma by the activated complement subcomponent C1r. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P09871
C1S_HUMAN
Homo sapiens
Complement C1s subcomponent

PDB Structure

PDB 4LOR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.
Venkatraman Girija, U., Gingras, A.R., Marshall, J.E., Panchal, R., Sheikh, M.A., Gal, P., Schwaeble, W.J., Mitchell, D.A., Moody, P.C., Wallis, R.
Proc.Natl.Acad.Sci.USA